The Role of High-Density Lipoprotein Cholesterol to Ganglion Cell Complex Thickness in Primary Open-Angle Glaucoma with a History of Type 2 Diabetes Mellitus

  • Sri Rejeki Sinaga
  • Masitha Dewi Sari
Keywords: type 2 diabetes, Primary open-angle glaucoma, Ganglion cell complex, HDL-C


Introduction: One of glaucoma’s risk factors is diabetes, which can be through changes in biochemical pathways, changes in blood flow by disorders of the endothelial auto regulation of blood vessels that cause glaucomatous and increases oxidative stress by lipid metabolism. Method: A cross-sectional study was organized at Universitas Sumatera Utara Hospital and partnership hospitals on 33 POAG patients with history of type 2 diabetes and 32 POAG patients without diabetes. All study subjects were examined for venous blood samples to measure HDL-C levels and assessed GCC thickness using SD-OCT. Results: The mean HDL-C in the POAG group with a history of type 2 diabetes was 48.24±11.53 mg/dL and in the other group was 44.59±8.30 mg/dL. The results of GCC thickness for each parameter and the relationship between HDL-C and GCC did not show a significant difference between the POAG with a history of type 2 diabetes groups and the POAG without diabetes groups (p>0.05). Conclusion: There was a decrease in GCC thickness values ​​(average GCC, superior GCC, and inferior GCC) and increase in FLV, GLV values ​​for POAG patients with type 2 diabetes compared to POAG patients without diabetes, but no statistically significant difference was found between two groups.