Evaluation of Neutrophil-to-Lymphocyte Ratio, Monocyte-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio as Predictor Factors on Diabetic Retinopathy

  • Dwi Atikah Sari
  • Delfi
  • Vanda Virgayanti
  • Masitha Dewi Sari
Keywords: neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-lymphocyte ratio, diabetic retinopathy

Abstract

Background: Diabetic retinopathy (DR) is a microvascular complication of type 2 diabetes mellitus. Inflammation is known to have a crucial role in the pathogenesis of DR. The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) are biomarkers of the inflammatory response. Aim: To determine the mean value of NLR, MLR and PLR as predictor factors in DR at the Universitas Sumatera Utara and Medan Baru Eye Hospital. Methods: This study was an observational analytic study with a case-control design. A total of 26 DR subjects as cases and 26 subjects non-DR as controls. Examination of NLR, MLR and PLR with routine blood test. Results: Mean values of NLR and PLR were higher in case group compared to controls (2.54(1.66), 131.62(78.87)) but the difference was not significant statistically (p=0.224, p=0.855). Mean MLR values were lower in case group compared to controls 0.25 (p=0.09). There were significant differences in visual acuity and blood sugar levels (p<0.001). NLR cannot be used as a predictor of DR (p=0.224 (95%CI=0.440-0.757). Conclusion: There is a significant difference between visual acuity and blood sugar levels between DR subjects and non-DR subjects. NLR, MLR and PLR cannot be used as a predictor of DR.
Published
2021-11-22
Section
Articles