Evaluations of Antioxidant and Anxiogenic Like Activities of Amomum aromaticum Roxb. Leaves

Nazim Uddin Emon, Sheikh Md. Kamrul Hasan., Md. Tohidul Islam Taki., Md. Solaman Uddin Sawon, Md. Munsur Alam

Abstract


The present study was planned to determine phytochemicals, antioxidants, and anxiogenic (anti-psychotic) activity of methanol extract of Amomum aromaticum roxb. Leaves (MEAA) in the laboratory using both in vitro and in vivo methods. In vitro antioxidant investigation was implemented by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, FeCl3 rfeducing power and total phenolic content study followed by established protocol described in previous. In vivo anxiogenic (anti-psychotic) activity was evaluated by Elevated Pluz Mazes (EPM) and Hole Board Test (HBT). The results showed the total phenolic content (36.56 ± 1.02 mg gallic acid/gm). In the anxiogenic activity, MEAA decreased the number of head dips in the hole-board test. In the case of the EPM test, this crude extract induced an anti-psychotic like effect rather than the anxiolytic effect in mice. To conclude these results suggested that this plant is a moderate source of antioxidants and it is not toxic. The results also demonstrate that MEAA possesses potent anxiogenic activity which could be used therapeutically for sleep disorders like hypersomnia as well as anti-psychotic disorders.

Keywords: Amomum aromaticum, DPPH (1, 1-Diphenyl-2-picrylhydrazyl), Free radical reducing power, Total phenolic content, Anxiety


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