Bertolotti’s Syndrome: Association of Lumbosacral Transitional Vertebrae (LSTV) With Low Back Pain (LBP) and Lumbosacral Degenerative Changes on Lumbosacral Radiograph
DOI:
https://doi.org/10.59573/emsj.8(6).2024.22Keywords:
lumbosacral transitional vertebrae, low back pain, Bertolotti’s syndromeAbstract
Introduction: Lumbosacral transitional vertebrae (LSTV) are common spinal congenital anomalies that affect both genders, and their association with low back pain has been debated in the literature for decades.
Objective: To assess the prevalence and association of LSTV and low back pain (LBP), evaluate the association between degenerative lumbosacral changes and LSTV using standard lumbosacral radiographs in a Nigerian population.
Methods: Standard anterior-posterior and lateral views of the lumbosacral spine of 399 patients who presented with low back pain (LBP) were reviewed and the transverse processes of L5 were graded according to Castellvi classification of LSTV.
Results: Out of the 399 radiographs reviewed, 168(42.1%) were males while 231(57.9%) were females with a ratio of 0.7:1. The prevalence of LSTV in the study was 30.1% with a higher rate in men than in women (35.1% vs 26.4%). Of the 120(30.1%) individuals with LSTV, 23.3% were Type I (dysplastic enlarged transverse process), 6.3% were Type II (pseudoarticulation), and 0.5% were type IV (one transverse process fused and one with pseudoarticulation). Of the 399 patients with low back pain, 218(54.6%) had degenerative changes of the lumbosacral spine while 181(45.4%) showed nil degenerative changes of the lumbosacral spine. The study also showed, 22(10.1%), 33(15.1%), 5(2.3%) and 12(5.5%) who had degenerative change had type IA, IB, IIA and IIB respectively while 18(9.9%), 20(11.0%), 4(2.2%) 4(2.2%) and 2(1.1%) without degenerative change had type IA, IB, IIA, IIB, and type 4 respectively.
Conclusion: Our study demonstrates an association between LSTV with LBP and the male gender shows a higher prevalence of LSTV when compared with the female gender.
References
Alinda, N.O., Mugarura, R., Malagala, J., Kisembo, H. (2022) Prevalence, patterns, functional disability of Bertolotti syndrome among patients with low back pain at Mulago National Referral Hospital. Afri Health Sci, 22(4), 168-177.
Amrita, G. (2019). Lumbosacral transitional vertebrae and its clinical implications. International Journal of Anatomy, 12(1), 25-30
Apazidis, A., Ricart, P.A., Diefenbach, C.M., Spivak, J.M. (2011). The prevalence of transitional vertebrae in the lumbar spine. Spine J, 11, 858-862.
Asra, S., Sohail, A.K., Munawar, H., Sadia, S., Hatem, A., Syed, O. A., Farheen, H., & Usman, K. (2017). Prevalence of Lumbosacral Transitional Vertebra in Individuals with Low Back Pain: Evaluation Using Plain Radiography and Magnetic Resonance Imaging. Asian Spine J, 11(6), 892-897.
Bertolotti, M. (1917). Contribute alla conoscenza dei vizi di differenzazione del rachide con speciale reguardo all assimilazione sacrale della v lombare. La Radiologia Medica, 4, 113–44.
Castellvi, A.E., Goldstein, L.A., Chan, D.P. (1984). Lumbosacral transitional vertebrae and their relationship with lumbar extradural defects. Spine, 9(5), 493–495.
Daniel, B.A., Tobias, A. M., Marília, G. S., Mirto, N. P., André, G. L., Jerônimo, B. M., Ricardo, R. (2009). Transitional Lumbosacral Vertebrae and Low Back Pain. Diagnostic Pitfalls and Management of Bertolotti’s Syndrome. Arq Neuropsiquiatr, 67(2-A), 268-272.
Daniel, P., Joel, J. J., Rana, P. K. (2019). Lumbosacral Transitional Vertebrae in Patients with Low Back Pain Radiological Classification and Morphometric Analysis. Journal of the Anatomical Society of India, 68(2), 123-128.
Delport, E.G., Cucuzzella, T.R., Kim, N., Marley, J., Pruitt, C., Delport AG. (2006) Lumbosacral transitional vertebrae: incidence in a consecutive patient series. Pain Physician, 9(1), 53–56.
Dionne, C. E., Dunn, K. M., Croft, P. R., Nachemson, A. L., Buchbinder, R., Walker, B. F., Wyatt, M., Cassidy, J. D., Rossignol, M., Leboeuf-Yde, C., Hartvigsen, J., Leino-Arjas, P., Latza, U., Reis, S., Gil Del Real, M. T., Kovacs, F. M., Oberg, B., Cedraschi, C., Bouter, L. M., Von Korff, M. (2008). A consensus approach toward the standardization of back pain definitions for use in prevalence studies. Spine, 33(1), 95– 103.
Eyo, M.U., Olofin, A., Noronha, C., Okanlawon, A. (2001). Incidence of lumbosacral transitional vertebrae in low back pain patients. West African Journal of Radiology, 8(1), 1–6.
Francisco. A., Andres, C., Mario, C., Jose, A. P. (2018). Bertolotti’s syndrome: An underdiagnosed cause for lower back pain. Journal of Surgical Case Reports, 10, 1-4.
Gökhan, K. K., Hüseyin, K. (2020). Does lumbosacral transitional vertebrae cause low back pain? J Turk Spinal Surg, 31(4), 234-8.
Hartvigsen, J., Hancock, M. J., Kongsted, A., Louw, Q., Ferreira, M. L., Genevay, S., Hoy, D., Karppinen, J., Pransky, G., Sieper, J., Smeets, R. J., Underwood, M., Buchbinder, R., Hartvigsen, J., Cherkin, D., Foster, N. E., Maher, C. G., Underwood, M., van Tulder, M., Woolf, A. (2018). What low back pain is and why we need to pay attention. The Lancet, 391(10137), 2356–2367.
Jaakko, H. (2024). Lumbosacral Transitional Vertebrae: Prevalence, Associated Degenerative Changes, And Association with Low Back Pain In Finnish Population. Acta universitatis ouluensis d Medica, 1769, 1-86.
Jancuska, J. M., Spivak, J. M., & Bendo, J. A. (2015). A Review of Symptomatic Lumbosacral Transitional Vertebrae: Bertolotti’s Syndrome. International Journal of Spine Surgery, 9, 42. https://doi.org/10.14444/2042.
Jönsson, B., Strömqvist, B., Egund, N. (1989). Anomalous lumbosacral articulations and low back pain. Evaluation and treatment. Spine, 14, 831-834.
Konin, G., Walz, D.M. (2010). Lumbosacral transitional vertebrae: classification, imaging findings, and clinical relevance. AJNR American journal of neuroradiology, 31(10), 1778-86.
Maher, C., Martin, U. R. (2017). Non-specific back pain. Lancet, 389(10070), 736-747.
McGrath, K., Schmidt, E., Rabah, N., Abubakr, M., & Steinmetz, M. (2021). Clinical assessment and management of Bertolotti Syndrome: A review of the literature. The Spine Journal, 21(8), 1286–1296.
Nardo, L., Alizai, H., Virayavanich, W., Liu, F., Hernandez, A., Lynch, J.A., Nevitt, M.C., McCulloch, C.E., Lane, N.E., and Link, T. M. (2012). Lumbosacral transitional vertebrae: Association with low back pain. Radiology, 265, 497-503.
Ogolo, D., Ajare, E. C., Okwunodulu, O., Ndubuisi, C. A., Mezue, W., Ohaegbulam, S. C. (2024). Bertolotti Syndrome: Prevalence and Clinical Implications in a West African Population. Journal of the Nigerian Academy of Medicine, 3(1), 24-31.
Oyinloye, O, I., Abdulkadir, A.Y., Babalola, M. (2009). Incidence and patterns of lumbosacral transitional vertebrae, in patients with low backpain in a Nigerian hospital. Niger. Q. J. Hosp. Med, 19(2), 96–99.
Paik, N.C., Lim, C.S., Jang, H.S. (2013). Numeric and morphological verification of lumbosacral segments in 8280 consecutive patients. Spine, 38(10), 573-8.
Park, S. C., Kang, M.S., Yang, J. H., & Kim, T.-H. (2023). Assessment and nonsurgical management of low back pain: A narrative review. The Korean Journal of Internal Medicine, 38(1), 16–26.
Reddy, R., Pooja, M. (2019). Bertolotti’s syndrome in low‑backache population: Classification and imaging findings. Tzu Chi Medical Journal, 31(2), 90–95.
Surendra, K. J., Amit, S., Raskesh, M., Manish, C., Anupama, T., Anil, K. J. (2023). Prevalence of lumbosacral transitional vertebra in patients with chronic low back pain: a descriptive cross-sectional study. Am J Neurodegener Dis,12(3), 89-9.
Tang, M., Yang, X.F., Yang, S.W., Han, P., Ma, Y.M., Yu, H. (2014). Lumbosacral transitional vertebra in a population-based study of 5860 individuals: Prevalence and relationship to low back pain. European journal of radiology, 83(9), 1679-82.
Ucar, B. Y., Uçar, D. E., Bulut, M., Azboy, I., & Demirtaş, A. (2013). Lumbosacral transitional vertebrae in low back pain population. J Spine, 2(125), 2. https://doi.org/10.4172/2165-7939.1000125
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