Correlation between Endothelin-1 (Et-1) and Myopia in Adolescents at Ta'dib Al-Syakirin Modern Islamic Boarding School Medan Johor District
Abstract
Background: Myopia is a refractive disorder caused by excessive axial lengthening. One of the factors affecting myopia is a cellular factor known as endothelin-1 (ET-1). Several studies have found that ET-1 is associated with various eye diseases such as glaucoma and diabetic retinopathy. However, studies relating to ET-1 to myopia are still limited. Aim: To determine the relationship between Endothelin-1 and myopia in adolescents. Methods: This study was an observational analytic study with a case-control design, conducted in October 2020. The population of this study was students aged 10-19 in Ta'dib Al-Syakirin Modern Islamic Boarding School Medan Johor Districts. Students were divided into two study groups, which were myopia and emmetropia groups. Results: Out of 48 subject, the case group (myopia) with 25 people and the control group (emmetropia) with 23 people. In the case group, the mean endothelin level is 93.21 ± 61.29 ng/L, while in the control group the mean endothelin level was lower 70.94 ± 15.70 ng/L. The results of the Mann-Whitney test showed a difference in the mean endothelin-1 levels between the case group and the control group (p = 0.012). From the Spearman correlation test, there was a significant correlation between endothelin-1 levels and myopia degree in the case group (p = 0.006). Conclusion: There was a correlation between endothelin-1 (ET-1) and myopia in adolescents at the Ta'dib Al-Syakirin Modern Islamic Boarding School Medan Johor Districts. High myopia patient was recommended to make a visit to ophthalmologist.Terms and conditions of Creative Commons Attribution 4.0 International License apply to all published manuscripts. This Journal is licensed under a Creative Commons Attribution 4.0 International License. This licence allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs and other platforms by providing appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
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