Correlation between Endothelin-1 (Et-1) and Myopia in Adolescents at Ta'dib Al-Syakirin Modern Islamic Boarding School Medan Johor District

  • Ade Marlina
  • Fithria Aldy
  • Masitha Dewi Sari
Keywords: Endothelin-1, myopia, emmetropia, adolescents


Background: Myopia is a refractive disorder caused by excessive axial lengthening. One of the factors affecting myopia is a cellular factor known as endothelin-1 (ET-1). Several studies have found that ET-1 is associated with various eye diseases such as glaucoma and diabetic retinopathy. However, studies relating to ET-1 to myopia are still limited. Aim: To determine the relationship between Endothelin-1 and myopia in adolescents. Methods: This study was an observational analytic study with a case-control design, conducted in October 2020. The population of this study was students aged 10-19 in Ta'dib Al-Syakirin Modern Islamic Boarding School Medan Johor Districts. Students were divided into two study groups, which were myopia and emmetropia groups. Results: Out of 48 subject, the case group (myopia) with 25 people and the control group (emmetropia) with 23 people. In the case group, the mean endothelin level is 93.21 ± 61.29 ng/L, while in the control group the mean endothelin level was lower 70.94 ± 15.70 ng/L. The results of the Mann-Whitney test showed a difference in the mean endothelin-1 levels between the case group and the control group (p = 0.012). From the Spearman correlation test, there was a significant correlation between endothelin-1 levels and myopia degree in the case group (p = 0.006). Conclusion: There was a correlation between endothelin-1 (ET-1) and myopia in adolescents at the Ta'dib Al-Syakirin Modern Islamic Boarding School Medan Johor Districts. High myopia patient was recommended to make a visit to ophthalmologist.