Prevalence of Congenital Anomalies in a Tertiary Hospital in Southern Brazil (1998-2015)

  • José Mauro Madi
  • Daiane de Oliveira Pereira Vergani
  • Pâmela Antoniazzi dos Santos
  • Vagner Reinaldo Zingalli Bueno Pereira
  • Bruna Lucchese Meinerz
  • Jessica Schiavenin
  • Rosa Maria Rahmi
  • Renato Luís Rombaldi
Keywords: congenital anomalies, newborn, prevalence, risk factors, mortality

Abstract

Objective: To evaluate the prevalence of congenital anomalies in a tertiary hospital in southern Brazil. Methods: Retrospective, cross-sectional study involving 22,317 births from 1998 to 2015 in the Gynecology and Obstetrics Department of the Caxias do Sul General Hospital /Caxias do Sul University. A descriptive univariate analysis was performed, followed by multivariate analysis, of the association between congenital anomalies and maternal, gestational, delivery, and newborn characteristics. Results: The prevalence of congenital malformations was 1.5% (95% CI 1.4-1.7), distributed as follows: genitourinary tract (18.2%), central nervous system (16.5%), musculoskeletal system (16.3%), cardiovascular system (9.7%), gastrointestinal tract (10.8%), and multiple malformations (28.5%). In the multivariate analysis, the following neonatal variables remained associated with congenital malformation: 5-minute Apgar score 0 to 3 [aHR=2.09 (1.21-2.12); p<0.010], 5-minute Apgar score 4 to 7 [aHR=2.83 (1.53-3.72); p<0.001], infant mortality [aHR=10.34 (7.79-13.72); p<0.001], stillbirth [aHR=25.56 (24.61-64.44); p<0.0001], and cesarean delivery [aHR=2.51 (1.99-3.16); p<0.001].
Published
2021-12-17
Section
Articles