Prevalence of Congenital Anomalies in a Tertiary Hospital in Southern Brazil (1998-2015)
Keywords:congenital anomalies, newborn, prevalence, risk factors, mortality
Objective: To evaluate the prevalence of congenital anomalies in a tertiary hospital in southern Brazil.
Methods: Retrospective, cross-sectional study involving 22,317 births from 1998 to 2015 in the Gynecology and Obstetrics Department of the Caxias do Sul General Hospital /Caxias do Sul University. A descriptive univariate analysis was performed, followed by multivariate analysis, of the association between congenital anomalies and maternal, gestational, delivery, and newborn characteristics.
Results: The prevalence of congenital malformations was 1.5% (95% CI 1.4-1.7), distributed as follows: genitourinary tract (18.2%), central nervous system (16.5%), musculoskeletal system (16.3%), cardiovascular system (9.7%), gastrointestinal tract (10.8%), and multiple malformations (28.5%). In the multivariate analysis, the following neonatal variables remained associated with congenital malformation: 5-minute Apgar score 0 to 3 [aHR=2.09 (1.21-2.12); p<0.010], 5-minute Apgar score 4 to 7 [aHR=2.83 (1.53-3.72); p<0.001], infant mortality [aHR=10.34 (7.79-13.72); p<0.001], stillbirth [aHR=25.56 (24.61-64.44); p<0.0001], and cesarean delivery [aHR=2.51 (1.99-3.16); p<0.001].
Terms and conditions of Creative Commons Attribution 4.0 International License apply to all published manuscripts. This Journal is licensed under a Creative Commons Attribution 4.0 International License. This licence allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs and other platforms by providing appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
A competing interest exists when professional judgment concerning the validity of research is influenced by a secondary interest, such as financial gain. We require that our authors reveal all possible conflicts of interest in their submitted manuscripts.
The Editor reserves the right to shorten and adjust texts. Significant changes in the text will be agreed with the Authors.