Relationship between Serum Levels of 25-Hydroxy Vitamin D and Ganglion Cell Complex (GCC) Thickness in Primary Open Angle Glaucoma Patients
AbstractBackground. Vitamin D is one of antioxidants regulating the protective function of nerve cells in central and optic nervous systems. Vitamin D actively works by suppressing oxidative damage, reducing the production of ROS, increasing the viability of larger cells, and preventing the secretion of pro-inflammatory cytokines, which in some studies is believed to be an independent risk factor for glaucoma. Objective. To determine the relationship between serum levels of 25-hydroxy vitamin D and ganglion cell complex (GCC) thickness in primary open-angle glaucoma (POAG) patients. Methods. Case control study design was conducted in 20 patients with POAG in comparison with 20 controls from the Ophthalmology Clinic in University of Sumatera Utara Hospital and affiliate hospitals from February to August 2021. Results. The overall values of average, superior, and inferior GCC were lower in POAG than in control groups, although no significant difference (p > 0.05) was found. FLV and GLV were higher in POAG group compared to control group, had a significant difference in FLV and GLV values case and control group (p<0.001). The median serum 25-hydroxy vitamin D in POAG and control group was 2.70 (1.31 - 27.5) and 4.20 (1.19 - 37.11) ng/mL, respectively, but no significant difference (p = 0.091) was found. No significant relationship between serum 25-hydroxy vitamin D and all parameters of GCC thickness was found in both case group and control group (p>0.05). Conclusion. Overall GCC thickness (average GCC, superior GCC, and inferior GCC) was lower in the POAG group compared to control group, although the relationship showed no difference between serum 25-hydroxy vitamin D and all parameters of GCC thickness.
Terms and conditions of Creative Commons Attribution 4.0 International License apply to all published manuscripts. This Journal is licensed under a Creative Commons Attribution 4.0 International License. This licence allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs and other platforms by providing appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
A competing interest exists when professional judgment concerning the validity of research is influenced by a secondary interest, such as financial gain. We require that our authors reveal all possible conflicts of interest in their submitted manuscripts.
The Editor reserves the right to shorten and adjust texts. Significant changes in the text will be agreed with the Authors.