Relationship between Serum Levels of 25-Hydroxy Vitamin D and Ganglion Cell Complex (GCC) Thickness in Primary Open Angle Glaucoma Patients

  • Muhammad Dede Gunawan
  • Masitha Dewi Sari
  • Taufik Ashar
Keywords: vitamin D, ganglion cell complex, POAG


Background. Vitamin D is one of antioxidants regulating the protective function of nerve cells in central and optic nervous systems. Vitamin D actively works by suppressing oxidative damage, reducing the production of ROS, increasing the viability of larger cells, and preventing the secretion of pro-inflammatory cytokines, which in some studies is believed to be an independent risk factor for glaucoma. Objective. To determine the relationship between serum levels of 25-hydroxy vitamin D and ganglion cell complex (GCC) thickness in primary open-angle glaucoma (POAG) patients. Methods. Case control study design was conducted in 20 patients with POAG in comparison with 20 controls from the Ophthalmology Clinic in University of Sumatera Utara Hospital and affiliate hospitals from February to August 2021. Results. The overall values of average, superior, and inferior GCC were lower in POAG than in control groups, although no significant difference (p > 0.05) was found. FLV and GLV were higher in POAG group compared to control group, had a significant difference in FLV and GLV values case and control group (p<0.001). The median serum 25-hydroxy vitamin D in POAG and control group was 2.70 (1.31 - 27.5) and 4.20 (1.19 - 37.11) ng/mL, respectively, but no significant difference (p = 0.091) was found. No significant relationship between serum 25-hydroxy vitamin D and all parameters of GCC thickness was found in both case group and control group (p>0.05). Conclusion. Overall GCC thickness (average GCC, superior GCC, and inferior GCC) was lower in the POAG group compared to control group, although the relationship showed no difference between serum 25-hydroxy vitamin D and all parameters of GCC thickness.