Anti-Dermatophytes Activity and Anti-Radical Power of Three Species of Terminalia on Four Dermatophytes Causing Superficial Infections

Abstract

In traditional settings, plants are used to treat skin conditions. This use exposes users to potential intoxication or the appearance of resistance to traditional treatment. The interest of a rational use incites to analyze the antidermatophytic and antioxidant potential of three plants of which: Terminalia ivorensis, Terminalia catappa and Terminalia superba. The antifungal tests were performed by the double dilution tube method on Microsporum canis, Trichophyton mentagrophytes, Trichophyton rubrum and Trichophyton soudanense. The hydroethanol extracts were subsequently used for the determination of the free radical scavenging activity by the DPPH reduction method. The extracts from these three plants have fungicidal activity on all four dermatophytes tested. The hydroethanol extract of T. ivorensis was the most active extract on the dermatophytes. The least sensitive dermatophyte was T. rubrum with a MFC of 195 µg/mL and the most sensitive dermatophyte was T. soudanense with a MFC of 24.34µg/mL. The IC50 values of the extracts are 21.15±52 µg/mL for Terminalia superba, 11.12±15 µg/mL for Terminalia catappa and 10.18±0.7µg/mL for Terminalia ivorensis against 9.67±0.28 µg/mL for vitamin C. This study confirmed the traditional use of these plants in the fight against dermatological diseases.