Prediction of Uric Acid on Renal Function among Adolescents: A Ten-Year Analysis
DOI:
https://doi.org/10.59573/emsj.7(3).2023.12Keywords:
Uric acid, Asymptomatic hyperuricemia, Renal function, AdolescentAbstract
Aims: The prevalence of hyperuricemia in adolescents is increasing with each passing year. During adolescence, hyperuricemia tends to develop into adult hyperuricemia and affects renal function. The study aims to explore the relationship between hyperuricemia values and renal function and examine predictors affecting renal function risk factors among senior high school students.
Methods: The retrospective study adopted 2011–2019 health examination database of 6597 male freshmen. The Chi-squared test, t-test, ROC curve, and logistic regression were used for analysis to find out the best cut-off points of hyperuricemia for male adolescents.
Results: The best cut-off values of uric acid were 6.5 mg/dL among male adolescents and the prevalence of hyperuricemia is 55.2% in male adolescents. Uric acid was the critical predictor of renal function and the risk of a worse eGFR (<90) in the uric acid >6.5 group was increased by 2.51 times compared with the < 6.5 group.
Conclusions: The school administrators should pay attention to the diet and body size of male adolescents and prevent obesity and diets that lead to hyperuricemia to promote health in adolescents. Adolescents with uric acid >6.5 mg/mL can be followed up if uric acid has different effects on renal function.
References
Bellomo, G., Venanzi, S., Verdura, C., Saronio, P., Esposito, A., & Timio, M. (2010). Association of uric acid with change in kidney function in healthy normotensive individuals. American journal of kidney diseases: the official journal of the National Kidney Foundation, 56(2), 264–272. https://doi.org/10.1053/j.ajkd.2010.01.019
Brucato A, Cianci F& Carnovale C. (2020). Management of hyperuricemia in asymptomatic patients: A critical appraisal. European Journal of internal Medicine, 74, 8-17. https://doi.org/10.1016/j.ejim.2020.01.001.
Canney, M., & Levin, A. (2020). Epidemiology of Chronic Kidney Disease—Scope of the Problem. Chronic Renal Disease, 75-89. https://doi.org/10.1016/B978-0-12-815876-0.00006-1
Chang, H.-Y., Pan, W.-H., Yeh, W. -T., & Tsai, K.- S. (2001). Hyperuricemia and gout in Taiwan: results from the Nutritional and Health Survey in Taiwan (1993-96). The Journal of Rheumatology, 28(7), 1640-1646. http://www.jrheum.org/content/28/7/1640
Chen, L., Han, S., Liu, F., Chen, S., Chen, X., & Chen, H. (2020). Prevalence of hyperuricemia in adolescents from 2000 to 2019 in Asia: A meta-analysis. [Manuscript submitted for publication] https://doi.org/10.21203/rs.3.rs- 16198/v2
Chen, X.-J., Eirin, A., Kane, G. C., Misra, S., Textor, S. C., Lerman, A., & Lerman, L. O. (2019). Impact of Serum Uric Acid Levels on Outcomes following Renal Artery Revascularization in Patients with Renovascular Disease. International journal of hypertension, 2019, 3872065. https://doi.org/10.1155/2019/3872065
Chen, S.-C., Huang, Y.-F., &Wang, J.-D. (2017). Hyperferritinemia and hyperuricemia may be associated with liver function abnormality in obese adolescents. PLoS ONE, 7(10), 8645. https://doi.org/10.1371/journal.pone.0048645
Chen, D.-Y., Lee, I.-Te., LIN, S.-C., Lin, H.-Y., Lin, H.-C., Chen, S.-M., Chen, S.-A., Chen, C.-H., Kuo, C.-F., Kuo, M.-C., Hsu, P.-F., Liu, M.-F., Tsai, W.-C., Hsieh, T.-Y., & Hsieh, S.-C. (2016). Taiwan guideline for the management of gout and hyperuricemia - updated 2016. Formosan Journal of Rheumatology, 30(2), 1-32. https://doi.org/ 10.6313/FJR.2016.12(01).01
Chuang, S.-Y., Lee, S.-C., Hsieh, -Y.T., & Pan, W.-H. (2011). Trends in Hyperuricemia and Gout Prevalence: Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008. Asia Pacific Journal of Clinical Nutrition, 20, (2), 301-308. https://doi.org/10.6133/apjcn.2011.20.2.20
DeBoer, M. D. (2019). Assessing and Managing the Metabolic Syndrome in Children and Adolescents. Nutrients, 11(8), 1788. https://doi.org/10.3390/nu11081788.
Ford, E. S., Li, Cook, S., & Choi, H. K. (2007). Serum concentrations of uric acid and the metabolic syndrome among US children and adolescents. Circulation, 115(19), 2526–2532. https://doi.org/doi:10.1161/CIRCULATIONAHA.106.657627
Goncalves, J. P., Ramos, E., Severo, M., Wong, M. C., Ong, K. K., Dunger, D. B., & Lopes, C. (2015). Serum uric acid and cardiovascular risk among Portuguese adolescents. Journal Adolesc Health, 56(4), 376-81. https://doi.org/ 10.1016/j.jadohealth.2014.11.010
Higa, S., Yoshida, M., Shima, D., Ii, Y., Kitazaki, S., Yamamoto, Y., & Fujimoto, Y. (2020). A Retrospective, cross-sectional study on the prevalence of hyperuricemia Using a Japanese Healthcare Database. Archives of Rheumatology, 35(1), 41-51. https://doi.org/10.5606/archrheumatol.2020.7330
Kuo, G.N., Chen, C.F., Yang, Y.I., et al. (2015). Taiwan Chronic Kidney Disease Clinical Guidelines. National Health Research Institutes.
Kubota M. (2019). Hyperuricemia in Children and Adolescents: Present Knowledge and Future Directions. Journal of nutrition and metabolism, 2019, 3480718. https://doi.org/10.1155/2019/3480718
Lee, J. H. (2019). Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: based on the 2016-2017 Korea National Health and Nutrition Examination Survey. Journal of the Korean Pediatric Society, 62(8), 317-323. https://dx.doi.org/10.3345%2Fkjp.2019.00444
Lee, M.-S., Wahlqvist, M.L., Yu, H.-L., & Pan, W.-H. (2007). Hyperuricemia and metabolic syndrome in Taiwanese children. Asia Pacific journal of clinical nutrition, 16(S2), 594 - 600. https://dx.doi.org/10.6133/apjcn.2007.16.s2.11
Li, L., Yang, C., Zhao, Y., Zeng, X., Liu, F., & Fu, P. (2014). Is hyperuricemia an independent risk factor for new-onset chronic kidney disease? a systematic review and meta-analysis based on observational cohort studies. BMC Nephrology, 15(1), 122-134. https://doi.org/10.1186/1471-2369-15-122
Liu, W.C., Hung, C.C., Chen, S.C., Yeh, S.M., Lin, M.Y., Chiu, Y.W., Kuo, M.C., Chang, J.M., Hwang, S.J., & Chen, H.C. (2012). Association of hyperuricemia with renal outcomes, cardiovascular disease, and mortality. Clinical Journal of the American Society of Nephrology, 7(4), 541-8. https://doi.org/ 10.2215/CJN.09420911.
Lin, K.-H., Yang, C.-C., & Hwu, C.-M. (2017). Recent Progress in Studies on the Relationship between Hyperuricemia and Hypertension in the Young. Journal of Internal Medicine of Taiwan, 28(6), 317-324. https://doi.org/10.6314/JIMT.2017.28(6).01
Lin, W.-T., Lee, C.-Y., Tsai, S., Huang, H.-L., Wu, P.-W., Chin, Y.-T., Seal, D. W., Chen, T., Chao, Y.-Y., & Lee, C.-H. (2019). Clustering of Metabolic Risk Components and Associated Lifestyle Factors: A Nationwide Adolescent Study in Taiwan. Nutrients, 11(3), 584. https://doi.org/10.3390/nu11030584
Loh, T. P., & Metz, M. P. (2015). Trends and physiology of common serum biochemistries in children aged 0–18 years. Pathology, 47(5), 452-461. https://doi.org/ 10.1097/PAT.0000000000000274
Ministry of Health and Welfare. (2018). Recommended BMI for Children and Adolescents. https://www.hpa.gov.tw/Pages/Detail.aspx?nodeid=542&pid=9547
Neogi, T., Jansen, T.L., T. A., Dalbeth, N., Fransen, J., Schumacher, H. R., Berendsen, D., Brown, M., Choi, H., Edwards, N.L., Janssens, H.J.E.M., Liote, F., Naden, R.P., Nuki, G., Ogdie, A., Perez-Ruiz, F., Saag, K., Singh, J.A., Sundy, J.S., Tausche, A.-K.…& Taylor, W.J. (2015). 2015 Gout Classification Criteria: An American College of Rheumatology/European League Against Rheumatism Collaborative Initiative. Arthritis & rheumatology, 67(10), 2557-2568. https://doi.org/ 10.1002/art.39254
Obermayr RP, Temml C, Gutjahr G et al. (2008). Elevated uric acid increases the risk for kidney disease. Journal of the American Society of Nephrology, 19(12), 2407-2413. DOI: 10.1681/ASN.2008010080
Prasad Sah, O. S., & Qing, Y. X. (2015). Associations Between Hyperuricemia and Chronic Kidney Disease: A Review, Nephro-urology monthly, 7(3), e27233. https://doi.org/ 10.5812/numonthly.7(3)2015.27233.
Rivera-Paredez, B., Mac?as-Kauffer, L., Fernandez-Lopez, J. C., Villalobos-Compar?n, M., Martinez-Aguilar, M. M., de la Cruz-Montoya, A., & Romero-Hidalgo, S. (2019). Influence of Genetic and Non-Genetic Risk Factors for Serum Uric Acid Levels and Hyperuricemia in Mexicans. Nutrients, 11(6), 1336. https://doi.org/ 10.3390/nu11061336
Shen, J.L. (2019). Research progress of chronic kidney disease and hyperuricemia. Clinical Medicine, 83(5), 309-313.https://doi.org/10.6666/ClinMed.201905_83(5).0051
Shih, Y. H., Wu, H. C., Pan, W. H., & Chang, H. Y. (2019). Increased coffee, tea, or other sugar-sweetened beverage consumption in adolescents is associated with less satisfactory dietary quality, body fatness and serum uric acid profiles over the past 18 years in Taiwan. Asia Pacific journal of clinical nutrition, 28(2), 371-382. https://doi.org/ 10.6133/apjcn.201906_28(2).0020.
Wilcox, W. D. (1996). Abnormal serum uric acid levels in children. The Journal of pediatrics, 128(6), 731-741. https://doi.org/10.1016/s0022-3476(96)70322-0.
Wu, Y.-D., & Kuo, T.-T. (2016). Taiwan guideline for the management of gout and clinical evidence of a good response to immunosuppressant therapy in a case of possible Bechet. Formosan Journal of Rheumatology, 30(2), 76-77. https://doi.org/ 10.6313/FJR.2016.12(01).08
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