Evaluations of Antioxidant and Anxiogenic Like Activities of Amomum aromaticum Roxb. Leaves
AbstractThe present study was planned to determine phytochemicals, antioxidants, and anxiogenic (anti-psychotic) activity of methanol extract of Amomum aromaticum roxb. Leaves (MEAA) in the laboratory using both in vitro and in vivo methods. In vitro antioxidant investigation was implemented by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, FeCl3 rfeducing power and total phenolic content study followed by established protocol described in previous. In vivo anxiogenic (anti-psychotic) activity was evaluated by Elevated Pluz Mazes (EPM) and Hole Board Test (HBT). The results showed the total phenolic content (36.56 ± 1.02 mg gallic acid/gm). In the anxiogenic activity, MEAA decreased the number of head dips in the hole-board test. In the case of the EPM test, this crude extract induced an anti-psychotic like effect rather than the anxiolytic effect in mice. To conclude these results suggested that this plant is a moderate source of antioxidants and it is not toxic. The results also demonstrate that MEAA possesses potent anxiogenic activity which could be used therapeutically for sleep disorders like hypersomnia as well as anti-psychotic disorders.Keywords: Amomum aromaticum, DPPH (1, 1-Diphenyl-2-picrylhydrazyl), Free radical reducing power, Total phenolic content, Anxiety
Terms and conditions of Creative Commons Attribution 4.0 International License apply to all published manuscripts. This Journal is licensed under a Creative Commons Attribution 4.0 International License. This licence allows authors to use all articles, data sets, graphics and appendices in data mining applications, search engines, web sites, blogs and other platforms by providing appropriate reference. The journal allows the author(s) to hold the copyright without restrictions and will retain publishing rights without restrictions.
A competing interest exists when professional judgment concerning the validity of research is influenced by a secondary interest, such as financial gain. We require that our authors reveal all possible conflicts of interest in their submitted manuscripts.
The Editor reserves the right to shorten and adjust texts. Significant changes in the text will be agreed with the Authors.